Ultra-high performance liquid chromatography-MS/MS (UHPLC-MS/MS) in practice: analysis of drugs and pharmaceutical formulations

development and validation of high performance liquid chromatography for determination of nystatin in pharmaceutical formulations

New High Performance Liquid Chromatography Method For Analysis Of Filgrastim In Pharmaceutical Formulations

Filgrastim is a human granulocyte colony-stimulating factor‚ which belongs to a family of cytokines. It is produced by recombinant DNA technology in genetically engineered Escherihia coli cells. Filgrastim has a biological action essential for proliferation and differentiation of hematopoetic and progenitor cells. Itis used for decreasing the risk of infection in cancer patients, who receive ch...

High Performance Liquid Chromatography (HPLC) in the pharmaceutical analysis

Introduction Drug manufacturing control requires high level and intensive analytical and chemical support of all stages to ensure the drug's quality and safety. The pharmacopeia constitutes a collection of recommended procedures for analysis and specifications for the determination of pharmaceutical substances, excipients, and dosage forms that is intended to serve as source material for refere...

Validated, reversed phase high performance liquid chromatography method for the estimation of capecitabine in pharmaceutical formulations

Reversed phase high performance liquid chromatographic method was developed and validated for estimation of Capecitabine in tablet dosage form. A Phenomenex Prodgy C18, 150x4.6 mm i.d, 5 μm partical size, with mobile phase consisting of mixed buffer of 0.005 M potassium dihydrogen orthophosphate and 0.005 M dipotassium hydrogen orthophosphate (pH 6.8) and acetonitrile in the ratio of 70:30 v/v ...

QSRR models of veterinary drugs in milk in ultra-performance liquid chromatography coupled to time of flight mass spectrometry

The veterinary drugs residues are also important pollutants found in milk, since veterinary drugs are commonly used in cattle management. Considering the role of milk in human nutrition and its wide consumption throughout the world, it is very important to ensure the milk quality. A quantitative structure–retention relationship (QSRR) was developed using the partial least square (PLS), Kernel P...